The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …

Cyclin-dependent kinase-2 (CDK2) is a member of protein kinase family. It plays an
important role in regulating various events of eukaryotic cell division cycle. Accumulated …

Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for
cancer progression. We report here a novel subseries of C-5-substituted anilinoquinazolines …

The development of sustainable methods directed towards the synthesis of molecules is due
to the heightened awareness and recognition of alternative eco-friendly and economical …

A series of metal complexes of Co (II), Zn (II), and Cu (II) of purine base Schiff base ligand L
1 6, 6′-((1E, 1′ E)-((7H-purine-2, 6-diyl) bis (azanylylidene)) bis (methanylylidene)) bis (2 …

A series of copper (II) complexes of Schiff bases derived from 7H-2, 6-diaminopurine and 4H-
3, 5-diamino-1, 2, 4-triazole with 2-pyridinecarbaldehyde, salicylaldehyde, 2, 4 …

Aberrant control of cyclin-dependent kinases (CDKs) is a central feature of the molecular
pathology of cancer. Iterative structure-based design was used to optimize the ATP …

Purines and related heterocycles substituted at C-2 with 4′-sulfamoylanilino and at C-6
with a variety of groups have been synthesized with the aim of achieving selectivity of …

Drug discovery is a complex and lengthy endeavor. 1 Many strategies exist to accelerate
target-to-clinical candidate selection, as well as to provide the highest quality candidate …

GANDI (G enetic A lgorithm-based de N ovo D esign of I nhibitors) is a computational tool for
automatic fragment-based design of molecules within a protein binding site of known …