Hypogonadotropic hypogonadism (HH) or secondary hypogonadism is defined as a clinical
syndrome that results from gonadal failure due to abnormal pituitary gonadotropin levels …

Microdissection testicular sperm extraction (microTESE) is considered the gold standard
method for surgical sperm retrieval among patients with non-obstructive azoospermia …

OBJECTIVE: To compare the efficacy and safety of recombinant human FSH (r-hFSH) and
hCG treatment for male hypogonadotropic hypogonadism (HH) in different populations and …

Highlights•Identifiable genetic abnormalities contribute to 15%–20% of the most severe
forms of male infertility, azoospermia.•Klinefelter syndrome, XXY, is the most common X …

Puberty is an important developmental stage during which reproductive capacity is attained.
The timing of puberty varies greatly among healthy individuals in the general population and …

Objective To determine the frequency of mutations of the gonadotropin-releasing hormone
receptor (GnRHR) and of the G protein-coupled receptor 54 (GPR54) genes in normosmic …

Hypogonadotrophic hypogonadism (HH) is characterized by delayed or absent pubertal
development secondary to gonadotrophin deficiency. HH can result from mutations of the …

We identified four unrelated patients (three female, one male) aged 20 to 30 years with
hypomyelination, pituitary hypogonadotropic hypogonadism, and hypodontia. Electron …

Puberty is initiated by gonadotropin-releasing hormone from the hypothalamus followed by
a complex sequence of endocrine changes and is regulated by both genetic and …

This review provides an update of the genes implicated in disorders of puberty, discusses
genes and pathways that may be involved in the timing of normal puberty, and suggests …