Sex and gender: modifiers of health, disease, and medicine
Clinicians can encounter sex and gender disparities in diagnostic and therapeutic
responses. These disparities are noted in epidemiology, pathophysiology, clinical …
responses. These disparities are noted in epidemiology, pathophysiology, clinical …
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
Understanding the impact of sex and gender in Alzheimer's disease: a call to action
RA Nebel, NT Aggarwal, LL Barnes, A Gallagher… - Alzheimer's & …, 2018 - Elsevier
Introduction Precision medicine methodologies and approaches have advanced our
understanding of the clinical presentation, development, progression, and management of …
understanding of the clinical presentation, development, progression, and management of …
Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of …
Background The risk of dementia is higher in women than men. The metabolic
consequences of estrogen decline during menopause accelerate neuropathology in …
consequences of estrogen decline during menopause accelerate neuropathology in …
Age, APOE and sex: triad of risk of Alzheimer's disease
Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …
Sex differences in the association of global amyloid and regional tau deposition measured by positron emission tomography in clinically normal older adults
Importance Mounting evidence suggests that sex differences exist in the pathologic
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …
Endogenous and exogenous estrogen exposures: how women's reproductive health can drive brain aging and inform Alzheimer's prevention
S Jett, N Malviya, E Schelbaum, G Jang… - Frontiers in Aging …, 2022 - frontiersin.org
After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …
The peri-menopause in a woman's life: a systemic inflammatory phase that enables later neurodegenerative disease
M McCarthy, AP Raval - Journal of neuroinflammation, 2020 - Springer
The peri-menopause or menopausal transition—the time period that surrounds the final
years of a woman's reproductive life—is associated with profound reproductive and …
years of a woman's reproductive life—is associated with profound reproductive and …