Sirtuins are NAD+-dependent protein deacylases/ADP-ribosyltransferases that have
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …

Significance: Developing evidence in the literature suggests that sirtuin 5 (SIRT5) may be
involved in metabolic reprogramming, an emerging hallmark of cancer by which neoplastic …

The cerebral ischemia injury can result in neuronal death and/or functional impairment,
which leads to further damage and dysfunction after recovery of blood supply. Cerebral …

Brown adipose tissue (BAT) is rich in mitochondria and plays important roles in energy
expenditure, thermogenesis, and glucose homeostasis. We find that levels of mitochondrial …

Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Background and Purpose: Sirt5 (Sirtuin 5) desuccinylates multiple metabolic enzymes and
plays an important role in maintaining energy homeostasis. The goal of this study was to …

Posttranslational modifications affect almost all proteins and are critical to a well-functioning
and diverse proteome; however, many modifications remain relatively unknown and …

Spinal cord injury (SCI) is one of the most incapacitating neurological disorders. It involves
complex pathological processes that include a primary injury and a secondary injury phase …

Epilepsy is characterized by recurrent seizures due to a perturbed balance between
glutamate and GABA neurotransmission. Our goal is to reveal the molecular mechanisms of …

Background and Purpose—Resveratrol, at least in part via SIRT1 (silent information
regulator 2 homologue 1) activation, protects against cerebral ischemia when administered …