[HTML][HTML] Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease
I Beltran-Hortelano, V Alcolea, M Font… - Bioorganic & medicinal …, 2022 - Elsevier
Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …
[HTML][HTML] Acid catalyzed one-pot approach towards the synthesis of curcuminoid systems: unsymmetrical diarylidene cycloalkanones, exploration of their single crystals …
In the present study crystalline unsymmetrical diarylidene ketone derivatives BNTP and
BDBC have been prepared by two sequential acid catalyzed aldol condensation reactions in …
BDBC have been prepared by two sequential acid catalyzed aldol condensation reactions in …
Facile preparation, characterization, SC-XRD and DFT/DTDFT study of diversely functionalized unsymmetrical bis-aryl-α, β-unsaturated ketone derivatives
The current research work is about the synthesis of diversely functionalized unsymmetrical
mono-carbonyl curcuminoids:(1E, 4E)-1-(2-methoxy-4-nitrophenyl)-5-(4-methoxyphenyl)-2 …
mono-carbonyl curcuminoids:(1E, 4E)-1-(2-methoxy-4-nitrophenyl)-5-(4-methoxyphenyl)-2 …
Diarylpentanoids, the privileged scaffolds in antimalarial and anti‐infectives drug discovery: A review
AH Ramli, SM Mohd Faudzi - Archiv der Pharmazie, 2023 - Wiley Online Library
Asia is a hotspot for infectious diseases, including malaria, dengue fever, tuberculosis, and
the pandemic COVID‐19. Emerging infectious diseases have taken a heavy toll on public …
the pandemic COVID‐19. Emerging infectious diseases have taken a heavy toll on public …
[HTML][HTML] In vitro activity and cell death mechanism induced by acrylonitrile derivatives against Leishmania amazonensis
CJ Bethencourt-Estrella, S Delgado-Hernández… - Bioorganic …, 2022 - Elsevier
Leishmaniasis produces approximately-one million of new cases annually, making it one of
the most important tropical diseases. As current treatments are not fully effective and are …
the most important tropical diseases. As current treatments are not fully effective and are …
[PDF][PDF] Combined QSAR modeling, molecular docking screening, and pharmacokinetics analyses for the design of novel 2, 6-diarylidene cyclohexanone analogs as …
FA Ugbe, GA Shallangwa… - Progress in Chemical …, 2023 - researchgate.net
Leishmaniasis, a neglected tropical disease is known to infect over 12 million people mainly
in tropical Africa, Southeast Asia, and Latin America [1]. Visceral leishmaniasis (VL) is the …
in tropical Africa, Southeast Asia, and Latin America [1]. Visceral leishmaniasis (VL) is the …
GC–MS based metabolomics strategy for cost-effective valorization of agricultural waste: Groundnut shell extracts and their biological inhibitory potential
M Arumugam, DB Manikandan, A Sridhar… - Waste and Biomass …, 2022 - Springer
Groundnut shells (GNS) make up about 20% of the weight of a dried peanut pod, indicating
a substantial amount of shell residue after groundnut processing. In primary screening …
a substantial amount of shell residue after groundnut processing. In primary screening …
[HTML][HTML] Anti-Leishmanial and cytotoxic activities of a series of maleimides: synthesis, biological evaluation and structure-activity relationship
In the present study, 45 maleimides have been synthesized and evaluated for anti-
leishmanial activities against L. donovani in vitro and cytotoxicity toward THP1 cells. All …
leishmanial activities against L. donovani in vitro and cytotoxicity toward THP1 cells. All …
Antiprotozoal QSAR modelling for trypanosomiasis (Chagas disease) based on thiosemicarbazone and thiazole derivatives
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a neglected
endemic infection that affects around 8 million people worldwide and causes 12,000 …
endemic infection that affects around 8 million people worldwide and causes 12,000 …
Antiproliferative activity of the dibenzylideneacetone derivate (E)-3-ethyl-4-(4-nitrophenyl) but‑3-en-2-one in Trypanosoma cruzi
JC de Paula, ABK Bakoshi, D Lazarin-Bidóia, ZU Din… - Acta tropica, 2020 - Elsevier
Chagas disease is one of the most prevalent neglected diseases in the world. The illness is
caused by Trypanosoma cruzi, a protozoan parasite with a complex life cycle and three …
caused by Trypanosoma cruzi, a protozoan parasite with a complex life cycle and three …