Bidentate directing groups: an efficient tool in C–H bond functionalization chemistry for the expedient construction of C–C bonds
S Rej, Y Ano, N Chatani - Chemical reviews, 2020 - ACS Publications
During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …
Hexafluoroisopropanol: the magical solvent for Pd-catalyzed C–H activation
Among numerous solvents available for chemical transformations, 1, 1, 1, 3, 3, 3-hexafluoro-
2-propanol (popularly known as HFIP) has attracted enough attention of the scientific …
2-propanol (popularly known as HFIP) has attracted enough attention of the scientific …
Transient directing groups for transformative C–H activation by synergistic metal catalysis
P Gandeepan, L Ackermann - Chem, 2018 - cell.com
The development of methods for the functionalization of otherwise inert C–H bonds is one of
the major foci in molecular syntheses. Recent advances have significantly improved the …
the major foci in molecular syntheses. Recent advances have significantly improved the …
Transient directing ligands for selective metal-catalysed C–H activation
C–H activation is a 'simple-to-complex'transformation that nature has perfected over millions
of years of evolution. Transition-metal-catalysed C–H activation has emerged as an …
of years of evolution. Transition-metal-catalysed C–H activation has emerged as an …
Overcoming the Limitations of γ-and δ-C–H Arylation of Amines through Ligand Development
L, X-Type transient directing groups (TDGs) based on a reversible imine linkage have
emerged as broadly useful tools for C–H activation of ketones and free amines. However …
emerged as broadly useful tools for C–H activation of ketones and free amines. However …
Collective approach to advancing C–H functionalization
HML Davies, D Morton - ACS Central Science, 2017 - ACS Publications
C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …
scientists from many disciplines. This Outlook describes the collaborative efforts within the …
PdII–Catalyzed Site-selective β- and γ-C(sp3)–H Arylation of Primary Aldehydes Controlled by Transient Directing Groups
YH Li, Y Ouyang, N Chekshin… - Journal of the American …, 2022 - ACS Publications
Pd (II)-catalyzed site-selective β-and γ-C (sp3)–H arylation of primary aldehydes is
developed by rational design of L, X-type transient directing groups (TDG). External 2 …
developed by rational design of L, X-type transient directing groups (TDG). External 2 …
Rhodium-catalyzed relay carbenoid functionalization of aromatic C–H bonds toward fused heteroarenes
X Wu, H Xiong, S Sun, J Cheng - Organic letters, 2018 - ACS Publications
A rhodium-catalyzed annulation between ethyl benzimidates and α-aroyl sulfur ylides was
developed, affording a series of pyrano [4, 3, 2-ij] isoquinoline derivatives in moderate to …
developed, affording a series of pyrano [4, 3, 2-ij] isoquinoline derivatives in moderate to …
Role of hexafluoroisopropanol in C–H activation
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) has emerged as an attractive tool in developing
and facilitating C–H activation/functionalizations. The hydrogen bond donating ability of this …
and facilitating C–H activation/functionalizations. The hydrogen bond donating ability of this …
Transient imines as 'next generation'directing groups for the catalytic functionalisation of C–H bonds in a single operation
S St John-Campbell, JA Bull - Organic & Biomolecular Chemistry, 2018 - pubs.rsc.org
C–H functionalisation promises a paradigm shift in synthetic planning. However, the
additional steps often required to install and remove directing groups currently detract from …
additional steps often required to install and remove directing groups currently detract from …