During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Among numerous solvents available for chemical transformations, 1, 1, 1, 3, 3, 3-hexafluoro-
2-propanol (popularly known as HFIP) has attracted enough attention of the scientific …

The development of methods for the functionalization of otherwise inert C–H bonds is one of
the major foci in molecular syntheses. Recent advances have significantly improved the …

C–H activation is a 'simple-to-complex'transformation that nature has perfected over millions
of years of evolution. Transition-metal-catalysed C–H activation has emerged as an …

L, X-Type transient directing groups (TDGs) based on a reversible imine linkage have
emerged as broadly useful tools for C–H activation of ketones and free amines. However …

C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …

Pd (II)-catalyzed site-selective β-and γ-C (sp3)–H arylation of primary aldehydes is
developed by rational design of L, X-type transient directing groups (TDG). External 2 …

A rhodium-catalyzed annulation between ethyl benzimidates and α-aroyl sulfur ylides was
developed, affording a series of pyrano [4, 3, 2-ij] isoquinoline derivatives in moderate to …

1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) has emerged as an attractive tool in developing
and facilitating C–H activation/functionalizations. The hydrogen bond donating ability of this …

C–H functionalisation promises a paradigm shift in synthetic planning. However, the
additional steps often required to install and remove directing groups currently detract from …