The biaryl structural motif is a predominant feature in many pharmaceutically relevant and
biologically active compounds. As a result, for over a century1 organic chemists have sought …

(Hetero) aryl groups directly connected by single Csp2–Csp2 bonds to heteroaryl moieties
are present as core structures in many biologically active compounds, 1 naturally-occurring …

In recent years, palladium‐catalyzed direct C2 or C5 arylation of heteroaromatic compounds
with aryl halides by C H bond activation has become a popular method for generating …

Traditional medicines have contributed greatly over the centuries to the discovery and
development of new therapeutic agents and indoloquinoline alkaloids may represent a new …

An iron-catalyzed strategy for the rapid synthesis of indolo [2, 3-c] quinolines has been
developed. This cascade reaction involving alcohol oxidation, nitro reduction, and oxidative …

Quinoline is a versatile heterocycle that is part of numerous natural products and countless
drugs. During the last decades, this scaffold also became widely used as ligand in …

An efficient and environmentally benign Cu-mediated method was developed for direct
cascade C–H/N–H annulation to construct polyheterocyclic indoloquinoline scaffolds. This …

In recent decades, a large number of reports related to the synthesis of N, O, and S
containing heterocycles have appeared owing to a wide variety of their biological activity …

Direct arylation is a useful method for the preparation of (hetero) aryl–aryl systems by C–H
bond cleavage. This procedure has several advantages such as the reduction of cost, time …

The antiprotozoal activities of three naturally occurring isomeric indoloquinoline alkaloids,
ie, cryptolepine (1), neocryptolepine (2), and isocryptolepine (3), and two dimeric …