Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

The adult zebrafish heart has a high capacity for regeneration following injury. However, the
composition of the regenerative niche has remained largely elusive. Here, we dissected the …

Aortic valve stenosis due to calcification of the valve leaflets is the most common valve
disease in the developed world. It is the third leading cause of cardiovascular disease. 1 …

Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …

Mesenchymal stem cells (MSCs) and their secreted exosomes exert a cardioprotective role
in jeopardized myocardium. However, the specific effects and underlying mechanisms of …

Cerebrovascular diseases such as ischemic stroke, brain hemorrhage, and subarachnoid
hemorrhage provoke cardiac complications such as heart failure, neurogenic stress-related …

Regenerative medicine is a translational field which combines tissue engineering and
molecular biology to construct spare organs or help injured or defective tissues to …

As an alternative to perfluorooctanesulfonate (PFOS), 6: 2 chlorinated polyfluorinated ether
sulfonate (commercial name: F-53B) has been used as a mist suppressant in Chinese …

Rationale: As a hallmark of various heart diseases, cardiac fibrosis ultimately leads to end-
stage heart failure. Anti-fibrosis is a potential therapeutic strategy for heart failure. Long …