Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

Cancer, a complex yet common disease, is caused by uncontrolled cell division and
abnormal cell growth due to a variety of gene mutations. Seeking effective treatments for …

Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Sensory experience remodels neural circuits in the early postnatal brain through
mechanisms that remain to be elucidated. Applying a new method of ultrastructural analysis …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …

Cadmium (Cd) is one of the most toxic metals without biological function, and its
accumulation in living organisms has been reported. The kidney is a target organ in Cd …

The process of programmed cell death, or apoptosis, is generally characterized by distinct
morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …