Viable Alzheimer's disease (AD) hypotheses must account for its age-dependence;
commonality; association with amyloid precursor protein, tau, and apolipoprotein E biology; …

In the last years, clusterin, a challenging and paradoxical apolipoprotein, has been of
growing interest amongst a rising number of scientists. This enigmatic protein is present in …

The brain, as one of the most lipid-rich organs, heavily relies on lipid transport and
distribution to maintain homeostasis and neuronal function. Lipid transport mediated by …

Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are
mostly found as terminal residues in glycan structures of glycoconjugates including both …

The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

Alzheimer's disease (AD) is a progressive neurological disorder that affects the central
nervous system (CNS), leading to memory and cognitive decline. In AD, the brain …

In recent years, Clusterin, a glycosylated protein with multiple biological functions, has
attracted extensive research attention. It is closely associated with the physiological and …

Psoriasis, a chronic and systemic inflammatory disorder characterized by activation of the
interleukin (IL)-23/IL-17 axis, may be associated with the intestinal microbiota through the so …

The ability to detect and target β cells in vivo can substantially refine how diabetes is studied
and treated. However, the lack of specific probes still hampers a precise characterization of …

Colorectal cancer is the third most diagnosed cancer, behind only breast and lung cancer. In
terms of overall mortality, it ranks second due to, among other factors, problems with …