Novel carbon skeletons activate human NicotinAMide Phosphoribosyl Transferase (NAMPT) enzyme in biochemical assay

KH Almeida, L Avalos-Irving, S Berardinelli… - PLoS …, 2023 - journals.plos.org
Nicotinamide adenine dinucleotide (NAD) is a central molecule in cellular metabolism that
has been implicated in human health, the aging process, and an array of human diseases …

Antiproliferative and genotoxic potential of xanthen-3-one derivatives

E Veljović, S ŠPIRTOVIĆ-HALILOVIĆ, S Muratović… - Acta …, 2019 - hrcak.srce.hr
Sažetak Twelve previously synthesized, biologically active 2, 6, 7-trihydroxyxanthen-3-one
derivatives were evaluated in vitro for antiproliferative activity. Compounds were screened …

Modelling of antiproliferative activity measured in HeLa cervical cancer cells in a series of xanthene derivatives

S Zukić, U Maran - SAR and QSAR in Environmental Research, 2020 - Taylor & Francis
Cancer remains one of the leading causes of death in humans, and new drug substances
are therefore being developed. Thus, the anti-cancer activity of xanthene derivatives has …

9-(4'-dimethylaminophenyl)-2, 6, 7-trihydroxy-xanthene-3-one is a Potentially Novel Antiplatelet Drug which Antagonizes the Effect of Thromboxane A2

L Applová, E Veljovic, S Muratovic… - Medicinal …, 2018 - ingentaconnect.com
Background: Currently, used oral antiplatelet drugs are both limited and associated with the
risk of treatment failure/resistance. Research in this area is hence highly desired. A series of …

Antimicrobial activity and docking study of synthesized xanthen-3-on derivatives

E Veljović, S Spirtovic-Halilovic… - Research Journal of …, 2018 - cer.ihtm.bg.ac.rs
Twelve previously synthesized biologically active 2, 6, 7-trihydroxy-9-aryl-3H-xanthen-3-one
derivatives (1-12) were evaluated in vitro for their antimicrobial activity against four bacteria …

[PDF][PDF] Synthesis and biological evaluation of xanthen-1, 8-dione derivatives

E Veljović, S Špirtović-Halilović… - Bulletin of the …, 2018 - hemija.pmf.unsa.ba
Xanthene and their derivatives are important heterocyclic compounds with interesting
biological activities, such as antibacterial (Lall, Hussein and Meyer, 2006), anti-inflammatory …

Effects of newly synthesized xanthene-3-ones on Pseudomonas aeruginosa–Experimental study on rats

A Smajović, E Veljović, M Čelebičić - Veterinaria, 2023 - veterinaria.unsa.ba
The need for new drugs that will have an antimicrobial effect is increasing every day.
Xanthenes are cyclic, organic compounds of natural, semi-synthetic or synthetic origin …

Toxicity testing of newly synthesized xanthene-3-ones after parenteral applications: an experimental study in rats (Rattus norvegicus)

A Smajović, M Katica, D Zavšnik, E Veljović… - Veterinaria, 2020 - veterinaria.unsa.ba
Xanthenes are organic compounds that can be of natural, semi-synthetic and synthetic
origin. Many studies indicate that xanthene and its derivatives have antibacterial, antifungal …

DNA Binding Affinity Assessment of Xanthene Compounds: In Vitro and In Silico Approach

E Veljović, A Osmanović, M Salihović… - Kemija u industriji …, 2023 - hrcak.srce.hr
Sažetak Xanthene derivatives are an important class of heterocyclic compounds with a wide
spectrum of pharmacological activities. In our previous investigations, we found the good …

Quantitative structure–activity relationships of xanthen-3-one and xanthen-1, 8-dione derivatives and design of new compounds with enhanced antiproliferative activity …

S Zukić, S Oljacic, K Nikolic, E Veljović… - Journal of …, 2021 - Taylor & Francis
Xanthene derivatives have become a group of molecules of great importance in discovering
of new anticancer drugs. Recent studies of our group performed on xanthen-3-one and …