Clinical extrapolation of the effects of dolutegravir and other HIV integrase inhibitors on folate transport pathways

MJ Zamek-Gliszczynski, X Zhang, J Mudunuru… - Drug Metabolism and …, 2019 - ASPET
Preliminary analysis of ongoing birth surveillance study identified evidence of potential
increased risk for neural tube defects (NTDs) in newborns associated with exposure to …

Absence of developmental and reproductive toxicity in animals exposed to dolutegravir

DJ Stanislaus, LM Posobiec, SB Laffan… - Birth Defects …, 2020 - Wiley Online Library
The success of new antiretroviral medicines for HIV resulted in a change to guidelines of
standard therapy where continuation of antiretroviral therapy is recommended to maintain …

Using in vitro gastrulation models to assess the teratogenicity of antiviral drugs: dolutegravir and remdesivir

L Kirkwood-Johnson - 2021 - scholarspace.manoa.hawaii.edu
About 1 in every 33 babies born in the US each year has a major structural birth defect,
which is one of the leading causes of infant death. Due to the prevalence of and severe risk …