Despite the number of in vitro assays that have been recently developed to identify
chemicals that interfere with the hypothalamic-pituitary-thyroid axis (HPT), the translation of …

Defects in endoplasmic reticulum (ER) proteostasis have been linked to diseases in multiple
organ systems. Here we examined the impact of perturbation of ER proteostasis in mice …

Congenital hypothyroidism with biallelic thyroglobulin (Tg protein, encoded by the TG gene)
mutation is an endoplasmic reticulum (ER) storage disease. Many patients (and animal …

Adult-onset primary hypothyroidism is commonly caused by iatrogenic or autoimmune
mechanisms; whether other factors might also contribute to adult hypothyroidism is unclear …

Congenital hypothyroidism is a genetic condition in which the thyroid gland fails to produce
sufficient thyroid hormone (TH), resulting in metabolic dysfunction and growth retardation …

Abstract Context Thyroglobulin (Tg), encoded by TG, is essential for thyroid hormone
synthesis. TG defects result in congenital hypothyroidism (CH). Most reported patients were …

Congenital hypothyroidism (CH) due to thyroglobulin (TG) variants causes very low serum
TG levels with normal or enlarged thyroid glands, depending on the severity of the defect …

Thyroglobulin (TG), the predominant glycoprotein of the thyroid gland, functions as matrix
protein in thyroid hormonegenesis. TG deficiency results in thyroid dyshormonogenesis …

Hydrogen sulfide (H 2 S) is a reducing gas molecule in mammalian cells that can be
endogenously synthesized by several enzymes, including cystathione β-synthase (CBS) …

Congenital hypothyroidism is a genetic condition in which the thyroid gland fails to produce
sufficient thyroid hormone (TH), resulting in metabolic dysfunction and growth retardation …