Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …
QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
Summary N 7-methylguanosine (m 7 G) modification, routinely occurring at mRNA 5′ cap
or within tRNAs/rRNAs, also exists internally in messenger RNAs (mRNAs). Although m 7 G …
or within tRNAs/rRNAs, also exists internally in messenger RNAs (mRNAs). Although m 7 G …
Maturing differentiated human pluripotent stem cells in vitro: methods and challenges
Human pluripotent stem cells (hPSCs), derived from individuals or genetically modified with
disease-related mutations and variants, have revolutionised studies of human disease …
disease-related mutations and variants, have revolutionised studies of human disease …
[HTML][HTML] RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development
Noncompaction cardiomyopathy is a common congenital cardiac disorder associated with
abnormal ventricular cardiomyocyte trabeculation and impaired pump function. The genetic …
abnormal ventricular cardiomyocyte trabeculation and impaired pump function. The genetic …
mRNA translational specialization by RBPMS presets the competence for cardiac commitment in hESCs
The blueprints of developing organs are preset at the early stages of embryogenesis.
Transcriptional and epigenetic mechanisms are proposed to preset developmental …
Transcriptional and epigenetic mechanisms are proposed to preset developmental …
In heart failure reactivation of RNA-binding proteins is associated with the expression of 1,523 fetal-specific isoforms
Reactivation of fetal-specific genes and isoforms occurs during heart failure. However, the
underlying molecular mechanisms and the extent to which the fetal program switch occurs …
underlying molecular mechanisms and the extent to which the fetal program switch occurs …
The Quaking RNA‐binding proteins as regulators of cell differentiation
DP Neumann, GJ Goodall… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
The RNA‐binding protein Quaking (QKI) has emerged as a potent regulator of cellular
differentiation in developmental and pathological processes. The QKI gene is itself …
differentiation in developmental and pathological processes. The QKI gene is itself …
The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes
P Montañés-Agudo, S Aufiero… - Cardiovascular …, 2023 - academic.oup.com
Aims In the heart, splicing factors orchestrate the functional properties of cardiomyocytes by
regulating the alternative splicing of multiple genes. Work in embryonic stem cells has …
regulating the alternative splicing of multiple genes. Work in embryonic stem cells has …
RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing
Aims RNA binding proteins play essential roles in mediating RNA splicing and are key post-
transcriptional regulators in the heart. Our recent study demonstrated that RBPMS (RNA …
transcriptional regulators in the heart. Our recent study demonstrated that RBPMS (RNA …
RBPMS2 is a myocardial-enriched splicing regulator required for cardiac function
Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-
transcriptional regulation of gene expression. Numerous RBPs have been implicated in …
transcriptional regulation of gene expression. Numerous RBPs have been implicated in …