Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …

Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …

Crucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer
from low-throughput and require considerable experimenter expertise. Automated patch …

Background: Enhanced diastolic calcium (Ca2+) release through ryanodine receptor type-2
(RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic …

Rationale: Junctional membrane complexes (JMCs) in myocytes are critical microdomains,
in which excitation–contraction coupling occurs. Structural and functional disruption of JMCs …

Although atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia, the
basic mechanisms underlying this disorder remain incompletely understood. During the past …

Atrial fibrillation (AF) is the most common tachyarrhythmia in clinical practice. Over decades
of research, a vast amount of knowledge has been gathered about the causes and …

Background: Abnormal calcium (Ca2+) release from the sarcoplasmic reticulum (SR)
contributes to the pathogenesis of atrial fibrillation (AF). Increased phosphorylation of 2 …