Considerable support exists for the roles of metabolism in modulating the carcinogenic
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the air, oils, water, and food
products we encounter every day. Among these exposures, food consumption is a major …

Although cytosolic glutathione S-transferase (GST) enzymes occupy a key position in
biological detoxification processes, two of the most relevant human isoenzymes, GSTT1-1 …

Abstract Glutathione S-transferases (GSTs), the versatile phase II biotransformation
enzymes, metabolize and detoxify a wide variety of toxic chemical compounds like …

Benzo [a] pyrene diol epoxide (BPDE)–DNA adducts are involved in the induction of p53
mutations and probably in the causation of human lung cancer associated with cigarette …

Benzo [a] pyrene, classified as a Group 1 carcinogen, is metabolized to B [a] P-7, 8-
dihydrodiol-9, 10-epoxide (BPDE), causing DNA mutations and eventually cancer. Quercetin …

DNA adducts associated with tobacco smoking could provide a marker of biologically
effective dose of tobacco carcinogens and improve individual cancer risk prediction. A …

Sumach (Rhus coriaria L.) is widely used as a spice. The aim of this study was the
investigation of its DNA-protective effects in humans and animals. Prevention of the …

The incidence of colonic toxicity has been epidemiologically linked to the consumption of
foods contaminated with benzo (a) pyrene (B [a] P). The present study investigated the …

Polycyclic aromatic hydrocarbons (PAHs) are associated with occupational exposure and
urban atmospheric pollution. Determination of the genotoxic properties of these compounds …