MS is heterogeneous with respect to clinical, genetic, radiographic, and pathologic features;
surrogate MRI, clinical, genetic, serologic, and/or CSF markers for each of the four …

Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease,
characterized by the formation of focal demyelinated plaques in the white matter of the …

There has been significant progress in our understanding of the pathology and
pathogenesis of central nervous system inflammatory demyelinating diseases …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Background and objectives Diagnosis of multiple sclerosis (MS) requires exclusion of
diseases that could better explain the clinical and paraclinical findings. A systematic process …

The relationship between plaque pathology and disease duration was examined in 15
patients with multiple sclerosis who died early in the course of their illness. Myelin‐stained …

Lesions of Baló's concentric sclerosis are characterized by alternating layers of myelinated
and demyelinated tissue. The reason for concentric demyelination in this variant of multiple …

Recent autopsy studies suggest that remyelinated shadow plaques located in otherwise
intact white matter are the outcome of a previous single episode of acute demyelination. In …

The neuropathology of demyelinating lesions in multiple sclerosis was studied in specimens
obtained by diagnostic needle biopsy during early stages of the disease. The lesions were …

Baló's concentric sclerosis (BCS) is a rare demyelinating disease considered to be a variant
of multiple sclerosis. Five BCS cases were diagnosed antemortem based on their typical …