Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation
Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …
disease biomarkers. However, certain critical steps of study design such as cohort selection …
Cardiorenal syndrome revisited
F Zannad, P Rossignol - Circulation, 2018 - Am Heart Assoc
Cardiorenal syndromes have been categorized into 5 clinical subtypes based on which
organ is perceived to be the primary precipitant of the vicious and interrelated cycle of …
organ is perceived to be the primary precipitant of the vicious and interrelated cycle of …
Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective …
N Tofte, M Lindhardt, K Adamova… - The lancet Diabetes & …, 2020 - thelancet.com
Background Microalbuminuria is an early sign of kidney disease in people with diabetes and
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …
Biomarkers of diabetic kidney disease
HM Colhoun, ML Marcovecchio - Diabetologia, 2018 - Springer
Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …
Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease
EYM Chung, M Ruospo, P Natale… - Cochrane Database …, 2020 - cochranelibrary.com
Background Treatment with angiotensin‐converting enzyme inhibitors (ACEi) and
angiotensin receptor blockers (ARB) is used to reduce proteinuria and retard the …
angiotensin receptor blockers (ARB) is used to reduce proteinuria and retard the …
[HTML][HTML] New progress in drugs treatment of diabetic kidney disease
J Wang, H Xiang, Y Lu, T Wu, G Ji - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Diabetic kidney disease (DKD) is not only one of the main complications of diabetes, but
also the leading cause of the end-stage renal disease (ESRD). The occurrence and …
also the leading cause of the end-stage renal disease (ESRD). The occurrence and …
Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future
Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …
A urinary proteome-based classifier for the early detection of decline in glomerular filtration
C Pontillo, L Jacobs, JA Staessen… - Nephrology Dialysis …, 2017 - academic.oup.com
Background. Chronic kidney disease (CKD) progression is currently assessed by a decline
in estimated glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion …
in estimated glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion …
Insights into predicting diabetic nephropathy using urinary biomarkers
NU Khan, J Lin, X Liu, H Li, W Lu, Z Zhong… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Diabetic nephropathy (DN) is a serious complication of diabetes caused by changes in the
structure and function of the kidneys. It is important to detect diagnostic biomarkers of DN at …
structure and function of the kidneys. It is important to detect diagnostic biomarkers of DN at …
Urinary proteomics predict onset of microalbuminuria in normoalbuminuric type 2 diabetic patients, a sub-study of the DIRECT-Protect 2 study
Background Early prevention of diabetic nephropathy is not successful as early interventions
have shown conflicting results, partly because of a lack of early and precise indicators of …
have shown conflicting results, partly because of a lack of early and precise indicators of …