Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation

ES Nakayasu, M Gritsenko, PD Piehowski, Y Gao… - Nature …, 2021 - nature.com
Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

Cardiorenal syndrome revisited

F Zannad, P Rossignol - Circulation, 2018 - Am Heart Assoc
Cardiorenal syndromes have been categorized into 5 clinical subtypes based on which
organ is perceived to be the primary precipitant of the vicious and interrelated cycle of …

Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective …

N Tofte, M Lindhardt, K Adamova… - The lancet Diabetes & …, 2020 - thelancet.com
Background Microalbuminuria is an early sign of kidney disease in people with diabetes and
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …

Biomarkers of diabetic kidney disease

HM Colhoun, ML Marcovecchio - Diabetologia, 2018 - Springer
Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease

EYM Chung, M Ruospo, P Natale… - Cochrane Database …, 2020 - cochranelibrary.com
Background Treatment with angiotensin‐converting enzyme inhibitors (ACEi) and
angiotensin receptor blockers (ARB) is used to reduce proteinuria and retard the …

[HTML][HTML] New progress in drugs treatment of diabetic kidney disease

J Wang, H Xiang, Y Lu, T Wu, G Ji - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Diabetic kidney disease (DKD) is not only one of the main complications of diabetes, but
also the leading cause of the end-stage renal disease (ESRD). The occurrence and …

Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future

A Latosinska, J Siwy, H Mischak, M Frantzi - Electrophoresis, 2019 - Wiley Online Library
Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …

A urinary proteome-based classifier for the early detection of decline in glomerular filtration

C Pontillo, L Jacobs, JA Staessen… - Nephrology Dialysis …, 2017 - academic.oup.com
Background. Chronic kidney disease (CKD) progression is currently assessed by a decline
in estimated glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion …

Insights into predicting diabetic nephropathy using urinary biomarkers

NU Khan, J Lin, X Liu, H Li, W Lu, Z Zhong… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Diabetic nephropathy (DN) is a serious complication of diabetes caused by changes in the
structure and function of the kidneys. It is important to detect diagnostic biomarkers of DN at …

Urinary proteomics predict onset of microalbuminuria in normoalbuminuric type 2 diabetic patients, a sub-study of the DIRECT-Protect 2 study

M Lindhardt, F Persson, P Zürbig… - Nephrology Dialysis …, 2017 - academic.oup.com
Background Early prevention of diabetic nephropathy is not successful as early interventions
have shown conflicting results, partly because of a lack of early and precise indicators of …