Mitochondrial signal transduction
M Picard, OS Shirihai - Cell Metabolism, 2022 - cell.com
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …
[HTML][HTML] What is a cell type and how to define it?
H Zeng - Cell, 2022 - cell.com
Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …
phenotypic properties at multiple levels, making them challenging to define, categorize, and …
[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …
types with specific spatial distribution patterns and structural and functional properties …
Maturation and circuit integration of transplanted human cortical organoids
Self-organizing neural organoids represent a promising in vitro platform with which to model
human development and disease,,,–. However, organoids lack the connectivity that exists in …
human development and disease,,,–. However, organoids lack the connectivity that exists in …
Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution
Spatial transcriptomics approaches have substantially advanced our capacity to detect the
spatial distribution of RNA transcripts in tissues, yet it remains challenging to characterize …
spatial distribution of RNA transcripts in tissues, yet it remains challenging to characterize …
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease
T Kamath, A Abdulraouf, SJ Burris, J Langlieb… - Nature …, 2022 - nature.com
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …
molecular and cellular mechanisms underlying cognitive impairment remain poorly …
Molecularly defined and spatially resolved cell atlas of the whole mouse brain
In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …
a wide range of functions. The enormous diversity and intricate organization of cells have …
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
Comparative cellular analysis of motor cortex in human, marmoset and mouse
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …