Extracellular vesicles as a next-generation drug delivery platform
IK Herrmann, MJA Wood, G Fuhrmann - Nature nanotechnology, 2021 - nature.com
Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of
life. There is compelling evidence that extracellular vesicles are involved in major (patho) …
life. There is compelling evidence that extracellular vesicles are involved in major (patho) …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Mesenchymal stromal cells: clinical challenges and therapeutic opportunities
J Galipeau, L Sensébé - Cell stem cell, 2018 - cell.com
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …
generation, and the outcomes of advanced clinical trials have fallen short of expectations …
Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose …
AJC Bloor, A Patel, JE Griffin, MH Gilleece, R Radia… - Nature medicine, 2020 - nature.com
The therapeutic potential of donor-derived mesenchymal stromal cells (MSCs) has been
investigated in diverse diseases, including steroid-resistant acute graft versus host disease …
investigated in diverse diseases, including steroid-resistant acute graft versus host disease …
Mesenchymal stem cell perspective: cell biology to clinical progress
MF Pittenger, DE Discher, BM Péault… - NPJ Regenerative …, 2019 - nature.com
The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …
Biological functions of mesenchymal stem cells and clinical implications
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …
Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years?
U Galderisi, G Peluso, G Di Bernardo - Stem cell reviews and reports, 2022 - Springer
Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …
Mesenchymal stromal cell homing: mechanisms and strategies for improvement
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …
Three-dimensional cell cultures in drug discovery and development
Y Fang, RM Eglen - Slas discovery: Advancing Life Sciences …, 2017 - journals.sagepub.com
The past decades have witnessed significant efforts toward the development of three-
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …
Mesenchymal stem cells and immunomodulation: current status and future prospects
F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …