The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Background. Chronic granulomatous disease (CGD) is due to defective nicotinamide
adenine dinucleotide phosphate oxidase activity and characterized by recurrent infections …

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) and a few related
mycobacteria, is a devastating disease, killing more than a million individuals per year …

Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency
disorder of phagocytes resulting in impaired killing of bacteria and fungi. A mutation in one …

Maintaining the redox balance between generation and elimination of reactive oxygen
species (ROS) is critical for health. Disturbances such as continuously elevated ROS levels …

Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in
250,000 individuals. The disease is caused by a lack of superoxide production by the …

Chronic granulomatous disease (CGD) is an innate immunodeficiency with a genetic defect
of the nicotinamide adenosine dinucleotide phosphate, reduced, oxidase components. This …