Expression of recombinant antibodies

A Frenzel, M Hust, T Schirrmann - Frontiers in immunology, 2013 - frontiersin.org
Recombinant antibodies are highly specific detection probes in research, diagnostics, and
have emerged over the last two decades as the fastest growing class of therapeutic proteins …

Plant molecular pharming for the treatment of chronic and infectious diseases

E Stoger, R Fischer, M Moloney… - Annual review of plant …, 2014 - annualreviews.org
Plant molecular pharming has emerged as a niche technology for the manufacture of
pharmaceutical products indicated for chronic and infectious diseases, particularly for …

[HTML][HTML] Plant glycoengineering for designing next-generation vaccines and therapeutic proteins

R Strasser - Biotechnology Advances, 2023 - Elsevier
Protein glycosylation has a huge impact on biological processes in all domains of life. The
type of glycan present on a recombinant glycoprotein depends on protein intrinsic features …

Advanced plant-based glycan engineering

L Montero-Morales, H Steinkellner - Frontiers in Bioengineering and …, 2018 - frontiersin.org
With respect to biomanufacturing, glycosylation is one of the most addressed post-
translational modifications, since it is well-known that the attachment of sugar residues …

Using glyco-engineering to produce therapeutic proteins

M Dicker, R Strasser - Expert Opinion on Biological Therapy, 2015 - Taylor & Francis
Introduction: Glycans are increasingly important in the development of new
biopharmaceuticals with optimized efficacy, half-life, and antigenicity. Current expression …

Synthetic glycobiology: parts, systems, and applications

W Kightlinger, KF Warfel, MP DeLisa… - ACS synthetic …, 2020 - ACS Publications
Protein glycosylation, the attachment of sugars to amino acid side chains, can endow
proteins with a wide variety of properties of great interest to the engineering biology …

[HTML][HTML] Plant glyco-biotechnology

J Schoberer, R Strasser - Seminars in cell & developmental biology, 2018 - Elsevier
Glycosylation is an important protein modification in all eukaryotes. Whereas the early
asparagine-linked glycosylation (N-glycosylation) and N-glycan processing steps in the …

N- and O-Glycosylation Pathways in the Microalgae Polyphyletic Group

E Mathieu-Rivet, N Mati-Baouche… - Frontiers in plant …, 2020 - frontiersin.org
The term microalga refers to various unicellular and photosynthetic organisms representing
a polyphyletic group. It gathers numerous species, which can be found in cyanobacteria (ie …

Engineering the plant secretory pathway for the production of next-generation pharmaceuticals

EA Margolin, R Strasser, R Chapman… - Trends in …, 2020 - cell.com
Production of biologics in plants, or plant molecular pharming, is a promising protein
expression technology that is receiving increasing attention from the pharmaceutical …

Recombinant mucin biotechnology and engineering

S Park, JCH Kuo, HL Reesink, MJ Paszek - Advanced drug delivery reviews, 2023 - Elsevier
Mucins represent a largely untapped class of polymeric building block for biomaterials,
therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically …