The predictable nature of DNA interactions enables the programmable assembly of highly
advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger …

Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups,
have been widely used in programmable bioengineering. Since nucleic acids are …

Double-stranded short interfering RNAs (siRNAs) mediate post-transcriptional inhibition of
gene expression in a variety of biological systems. However, human liver cells show poor …

The vast majority of human cancers express telomerase activity, while most human somatic
cells do not have detectable telomerase activity. Since telomerase plays a critical role in cell …

The rapid growth of biotechnology has triggered an increasing demand for modified
oligonucleotides dedicated mostly to diagnostic and therapeutic applications. The plethoric …

Nuclease-resistant aptamers identified from randomized nucleic acid libraries represent a
novel class of drug candidates. Aptamers are synthesized chemically and therefore can be …

Oligonucleotides, including antisense oligonucleotides and siRNA, are promising
therapeutic agents against a variety of diseases. Effective delivery of these molecules is …

Olignucleotide-based drugs show promise as a novel form of chemotherapy. Among the
hurdles that have to be overcome on the way of applicable nucleic acid therapeutics …

Small interfering RNA (siRNA), antisense oligonucleotides (ODNs), ribozymes and
DNAzymes have emerged as sequence-specific inhibitors of gene expression that may have …

Nucleoside , nucleotide and oligonucleotide based amphiphiles : a successful marriage of
nucleic acids with lipids - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/B719280K …