Tetraspanins are molecular scaffolds that distribute proteins into highly organized
microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have …

Overview Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast
cells (MCs) in extra‐cutaneous organs. Diagnosis The major criterion is presence of …

Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently
defined by recurrent cytogenetic abnormalities, including rearrangements involving the core …

Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid
leukemia (AML) have made enormous progress during the past decades. Because AML is a …

Despite major improvements in outcome over the past decades, acute myeloid leukemia
(AML) remains a life-threatening malignancy in children, with current survival rates of∼ …

Purpose Gastrointestinal stromal tumors (GISTs) commonly harbor oncogenic mutations of
the KIT or platelet-derived growth factor alpha (PDGFRA) kinases, which are targets for …

Purpose To analyze the prognostic impact of mutated KIT (mut KIT) in core-binding factor
acute myeloid leukemia (AML) with inv (16)(p13q22) and t (8; 21)(q22; q22). Patients and …

Pediatric acute myeloid leukemia (AML) represents 15%–20% of all pediatric acute
leukemias. Survival rates have increased over the past few decades to~ 70%, due to …

Objective: To analyze the clinical outcome and the prognostic factor in pediatric patients with
core binding factor-acute myeloid leukemia (CBF-AML). Methods: A total of 121 newly …

Adult mastocytosis is an incurable clonal disease associated with c-KIT mutations, mostly in
exon 17 (D 816 V). In contrast, pediatric mastocytosis often spontaneously regresses and is …