Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …

Deregulated WNT signaling has been shown to favor malignant transformation, tumor
progression, and resistance to conventional cancer therapy in a variety of preclinical and …

Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children,
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …

In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based
on their location within the liver lobule. However, it is unclear whether this spatial variation …

The mammalian liver is composed of repeating hexagonal units termed lobules. Spatially
resolved single-cell transcriptomics has revealed that about half of hepatocyte genes are …

During embryonic development, naive pluripotent epiblast cells transit to a formative state.
The formative epiblast cells form a polarized epithelium, exhibit distinct transcriptional and …

Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Here, we
unfold genome-wide transcriptional and chromatin landscapes of β-catenin–TCF3/4–TLE …

In mammals, Wnt/β-catenin signaling features prominently in stem cells and cancers, but
how and for what purposes have been matters of much debate. In this review, we summarize …

T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins (TCFs) from the High
Mobility Group (HMG) box family act as the main downstream effectors of the Wnt signaling …

Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the
capacity to generate any type of cell in the body, and therefore not only hold great promise …