Vasculogenesis, angiogenesis and arteriogenesis represent three crucial mechanisms
involved in the formation and maintenance of the vascular network in embryonal and post …

Ectopic thyroid tissue remains a rare developmental abnormality involving defective or
aberrant embryogenesis of the thyroid gland during its passage from the floor of the primitive …

A quarter of patients with essential thrombocythemia or primary myelofibrosis carry a driver
mutation of CALR, the calreticulin gene. A 52-bp deletion (type 1) and a 5-bp insertion (type …

Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday
production and release of millions of platelets into the bloodstream. Since the discovery and …

Basal forebrain neurons increase cortical blood flow by releasing acetylcholine (Ach), which
stimulates endothelial cells (ECs) to produce the vasodilating gasotransmitter, nitric oxide …

Background Although there is no agreement on a definition of elderly, commonly an age
cutoff of≥ 65 or 75 years is used. Nowadays most of malignancies requiring surgical …

Intracellular Ca2+ signaling drives angiogenesis and vasculogenesis by stimulating
proliferation, migration, and tube formation in both vascular endothelial cells and endothelial …

Endothelial progenitor cells (EPCs) have recently been shown to promote the angiogenic
switch in solid neoplasms, thereby promoting tumour growth and metastatisation. The …

An increase in intracellular Ca2+ concentration plays a key role in the establishment of
many cancer hallmarks, including aberrant proliferation, migration, invasion, resistance to …

An increase in intracellular Ca 2+ concentration ([Ca 2+] i) regulates a plethora of functions
in the cardiovascular (CV) system, including contraction in cardiomyocytes and vascular …