[PDF][PDF] VEGF in signaling and disease: beyond discovery and development
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …
understanding of vasculogenesis and angiogenesis during development and physiological …
Overcoming resistance to tumor-targeted and immune-targeted therapies
Resistance to anticancer therapies includes primary resistance, usually related to lack of
target dependency or presence of additional targets, and secondary resistance, mostly …
target dependency or presence of additional targets, and secondary resistance, mostly …
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers
Although single-gene perturbation screens have revealed a number of new targets,
vulnerabilities specific to frequently altered drivers have not been uncovered. An important …
vulnerabilities specific to frequently altered drivers have not been uncovered. An important …
The emerging clinical relevance of genomics in cancer medicine
The combination of next-generation sequencing and advanced computational data analysis
approaches has revolutionized our understanding of the genomic underpinnings of cancer …
approaches has revolutionized our understanding of the genomic underpinnings of cancer …
Targeting alterations in the RAF–MEK pathway
R Yaeger, RB Corcoran - Cancer discovery, 2019 - AACR
The MAPK pathway is one of the most commonly mutated oncogenic pathways in cancer.
Although RAS mutations are the most frequent MAPK alterations, less frequent alterations in …
Although RAS mutations are the most frequent MAPK alterations, less frequent alterations in …
Radiomics: images are more than pictures, they are data
In the past decade, the field of medical image analysis has grown exponentially, with an
increased number of pattern recognition tools and an increase in data set sizes. These …
increased number of pattern recognition tools and an increase in data set sizes. These …
From melanocytes to melanomas
AH Shain, BC Bastian - nature reviews Cancer, 2016 - nature.com
Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on
the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic …
the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic …
Ten years of anti-vascular endothelial growth factor therapy
N Ferrara, AP Adamis - Nature reviews Drug discovery, 2016 - nature.com
The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …
[HTML][HTML] Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma
Background Combined BRAF and MEK inhibition, as compared with BRAF inhibition alone,
delays the emergence of resistance and reduces toxic effects in patients who have …
delays the emergence of resistance and reduces toxic effects in patients who have …
First-in-class ERK1/2 inhibitor ulixertinib (BVD-523) in patients with MAPK mutant advanced solid tumors: results of a phase I dose-escalation and expansion study
RJ Sullivan, JR Infante, F Janku, DJL Wong… - Cancer discovery, 2018 - AACR
Abstract Ulixertinib (BVD-523) is an ERK1/2 kinase inhibitor with potent preclinical activity in
BRAF-and RAS-mutant cell lines. In this multicenter phase I trial (NCT01781429), 135 …
BRAF-and RAS-mutant cell lines. In this multicenter phase I trial (NCT01781429), 135 …