Drug nanoparticle formulation using ascorbic acid derivatives

K Moribe, W Limwikrant, K Higashi… - Journal of drug …, 2011 - Wiley Online Library
Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have
recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside …

Topical delivery of antioxidants

A Ascenso, H Margarida Ribeiro… - Current drug …, 2011 - ingentaconnect.com
Reactive oxygen species (ROS) and free radicals have been implicated in a number of
diseases and disorders, and the skin, for its localization, is exposed to a large number of …

Direct biocatalysed synthesis of first sulfur-, selenium-and tellurium-containing l-ascorbyl hybrid derivatives with radical trapping and GPx-like properties

D Tanini, B Lupori, G Malevolti, M Ambrosi… - Chemical …, 2019 - pubs.rsc.org
6-OL-Ascorbyl selenoesters, thioesters and telluroesters can be efficiently and directly
prepared from L-ascorbic acid and suitable functionalised chalcogenoesters through lipase …

Alkyl esters of l-ascorbic acid: Stability, surface behaviour and interaction with phospholipid monolayers

M Mottola, RV Vico, ME Villanueva… - Journal of Colloid and …, 2015 - Elsevier
Abstract l-ascorbic acid alkyl esters (ASC n) are molecules of pharmaceutical interest for
their amphiphilic nature and proposed antioxidant power. In contrast to l-ascorbic acid, ASC …

A Vaccine Based on Kunitz-Type Molecule Confers Protection Against Fasciola hepatica Challenge by Inducing IFN-γ and Antibody Immune Responses Through IL …

L Silvane, DP Celias, PA Romagnoli… - Frontiers in …, 2020 - frontiersin.org
Fasciola hepatica is helminth parasite found around the world that causes fasciolosis, a
chronic disease affecting mainly cattle, sheep, and occasionally humans. Triclabendazole is …

Development of an infusion method for encapsulating ascorbyl palmitate in V-type granular cold-water swelling starch

DM Dries, SV Gomand, SC Pycarelle, M Smet… - Carbohydrate …, 2017 - Elsevier
Certain lipophilic components can be inserted very efficiently as guest molecule in the
existing single helical amylose cavities in V H-type crystalline granular cold-water swelling …

Multidrug idebenone/naproxen co‐loaded aspasomes for significant in vivo anti‐inflammatory activity

N d'Avanzo, MC Cristiano, L Di Marzio… - …, 2022 - Wiley Online Library
The use of proper nanocarriers for dermal and transdermal delivery of anti‐inflammatory
drugs recently gained several attentions in the scientific community because they pass intact …

The Rheological Properties of Lipid Monolayers Modulate the Incorporation of l-Ascorbic Acid Alkyl Esters

YLM Zulueta Díaz, M Mottola, RV Vico, N Wilke… - Langmuir, 2016 - ACS Publications
In this work, we tested the hypothesis that the incorporation of amphiphilic drugs into lipid
membranes may be regulated by their rheological properties. For this purpose, two …

Optimization of skin permeation and distribution of ibuprofen by using nanostructures (coagels) based on alkyl vitamin C derivatives

V Saino, D Monti, S Burgalassi, S Tampucci… - European journal of …, 2010 - Elsevier
In this investigation two vitamin C-based-6-O-ascorbic acid esters (ASC12 and ASC16), able
to form liquid–crystal structures (coagels) was evaluated for their potential usefulness to …

Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against …

AL Chiodetti, MF Sánchez Vallecillo, JS Dolina… - Frontiers in …, 2018 - frontiersin.org
There is a need for new vaccine adjuvant strategies that offer both vigorous antibody and T-
cell mediated protection to combat difficult intracellular pathogens and cancer. To this aim …