Treatment strategies for cryptococcal infection: challenges, advances and future outlook

KR Iyer, NM Revie, C Fu, N Robbins… - Nature Reviews …, 2021 - nature.com
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …

Cryptococcus neoformans, a global threat to human health

Y Zhao, L Ye, F Zhao, L Zhang, Z Lu, T Chu… - Infectious Diseases of …, 2023 - mednexus.org
Background Emerging fungal pathogens pose important threats to global public health. The
World Health Organization has responded to the rising threat of traditionally neglected …

A global view on fungal infections in humans and animals: opportunistic infections and microsporidioses

S Gnat, D Łagowski, A Nowakiewicz… - Journal of Applied …, 2021 - academic.oup.com
After cardiovascular diseases, infectious diseases are the second most common cause of
death worldwide. Although these infections are caused mainly by viruses or bacteria, a …

Resistance to antifungal drugs

R Ben-Ami, DP Kontoyiannis - Infectious Disease Clinics, 2021 - id.theclinics.com
The burden of human disease associated with fungal infections is generally
underappreciated, with estimates indicating as many as 150 million persons infected …

A One Health approach to overcoming fungal disease and antifungal resistance

M Woods, JA McAlister… - WIREs Mechanisms of …, 2023 - Wiley Online Library
The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …

Recent progress in the discovery of antifungal agents targeting the cell wall

W Liu, L Yuan, S Wang - Journal of medicinal chemistry, 2020 - ACS Publications
Due to the limit of available treatments and the emergence of drug resistance in the clinic,
invasive fungal infections are an intractable problem with high morbidity and mortality. The …

[HTML][HTML] Natural products targeting the synthesis of β (1, 3)-D-glucan and chitin of the fungal cell wall. Existing drugs and recent findings

MÁ Curto, E Butassi, JC Ribas, LA Svetaz, JCG Cortés - Phytomedicine, 2021 - Elsevier
Background: During the last three decades systemic fungal infections associated to
immunosuppressive therapies have become a serious healthcare problem. Clinical …

Addressing microbial resistance worldwide: challenges over controlling life-threatening fungal infections

L Martins-Santana, CP Rezende, A Rossi… - Pathogens, 2023 - mdpi.com
Fungal infections are a serious global concern because of their ability to spread and
colonize host tissues in immunocompromised individuals. Such infections have been …

Multidrug-resistant Trichosporon species: underestimated fungal pathogens posing imminent threats in clinical settings

A Arastehfar, JN de Almeida Júnior… - Critical Reviews in …, 2021 - Taylor & Francis
Species of Trichosporon and related genera are widely used in biotechnology and, hence,
many species have their genome sequenced. Importantly, yeasts of the genus Trichosporon …