Breast cancer, a formidable global health challenge, needs continuous translational
research to understand the complexity of mechanisms and improve therapeutic and …

Simple Summary Despite an intensive research effort in the past few decades, prostate
cancer (PC) remains a top cause of cancer death in men, particularly in the developed …

Proteomic signatures associated with clinical measures of more aggressive cancers could
yield molecular clues as to disease drivers. Here, utilizing the Clinical Proteomic Tumor …

Pancreatic cancer (PC) remains a major cause of cancer-related deaths primarily due to its
inherent potential of therapy resistance. Checkpoint inhibitors have emerged as promising …

Platinum-based chemotherapy is the standard first-line treatment for oral squamous cell
carcinoma (OSCC) that is inoperable, recurrent, or metastatic. Platinum sensitivity is a major …

Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing
cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle …

FOXG1 is a critical transcription factor in human brain where loss-of-function mutations
cause a severe neurodevelopmental disorder, while increased FOXG1 expression is …

Although microtubule-associated serine/threonine kinase-like (MASTL) is a promising target
for selective anticancer treatment, MASTL inhibitors with nano range potency and antitumor …

Microtubule-associated serine-threonine kinase-like (MASTL) has recently been identified
as an oncogenic kinase given its overexpression in numerous cancers. Our group has …

Microtubule-associated serine/threonine kinase-like (MASTL)(or Greatwall kinase (GWL)) is
an important cell cycle regulating kinase that regulates the G2-M transition. Uncontrolled …