Antifungal therapy: new advances in the understanding and treatment of mycosis

L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Antifungal resistance in dermatophytes: Recent trends and therapeutic implications

A Khurana, K Sardana, A Chowdhary - Fungal Genetics and Biology, 2019 - Elsevier
Dermatophytoses or tinea refers to superficial fungal infection of keratinized tissues.
Although generally considered easy to treat, recalcitrant infections, presenting as extensive …

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

S Gnat, D Łagowski… - Journal of applied …, 2020 - academic.oup.com
Dermatophytes are the aetiological factors of a majority of superficial fungal infections. What
distinguishes them from other pathogenic filamentous fungi is their unique ability to degrade …

Dermatophyte resistance to antifungal drugs: mechanisms and prospectus

NM Martinez-Rossi, TA Bitencourt, NTA Peres… - Frontiers in …, 2018 - frontiersin.org
Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized
structures present in nails, skin, and hair, causing superficial infections known as …

State-of-the-art dermatophyte infections: epidemiology aspects, pathophysiology, and resistance mechanisms

NM Martinez-Rossi, NTA Peres, TA Bitencourt… - Journal of Fungi, 2021 - mdpi.com
The burden of fungal infections is not widely appreciated. Although these infections are
responsible for over one million deaths annually, it is estimated that one billion people are …

Antifungal resistance mechanisms in dermatophytes

NM Martinez-Rossi, NTA Peres, A Rossi - Mycopathologia, 2008 - Springer
Although fungi do not cause outbreaks or pandemics, the incidence of severe systemic
fungal infections has increased significantly, mainly because of the explosive growth in the …

[HTML][HTML] Dermatophytes: host-pathogen interaction and antifungal resistance

NTA Peres, FCA Maranhão, A Rossi… - Anais brasileiros de …, 2010 - SciELO Brasil
As micoses cutâneas estão entre as infecções mais comuns em humanos e se tornaram um
importante problema de saúde pública, principalmente por causarem infecções invasivas …

Antimicrobials and resistance part II: Antifungals, antivirals, and antiparasitics

FF Muhaj, SJ George, CD Nguyen, SK Tyring - Journal of the American …, 2022 - Elsevier
The available antifungal armamentarium consists of only a few drug classes, many limited in
their use by significant toxicities and dangerous drug interactions. Rising opportunistic …

Dermatophyte virulence factors: identifying and analyzing genes that may contribute to chronic or acute skin infections

RR Achterman, TC White - International journal of microbiology, 2012 - Wiley Online Library
Dermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal
pathogens, are able to cause disease in immunocompetent individuals. They infect …

Generating and testing molecular hypotheses in the dermatophytes

TC White, BG Oliver, Y Gräser, MR Henn - Eukaryotic cell, 2008 - Am Soc Microbiol
Dermatophytes are the most common cause of fungal infections worldwide, impacting
millions of individuals annually. In the United States alone, this translates into an economic …