Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

Methyl groups are important for numerous cellular functions such as DNA methylation,
phosphatidylcholine synthesis, and protein synthesis. The methyl group can directly be …

Range expansions are extremely common, but have only recently begun to attract attention
in terms of their genetic consequences. As populations expand, demes at the wave front …

Maternal supplementation with folic acid is known to reduce the incidence of neural tube
defects (NTDs) by as much as 70%. Despite the strong clinical link between folate and …

Women have higher requirements for folate during pregnancy. An optimal folate status must
be achieved before conception and in the first trimester when the neural tube closes. Low …

Eggs contain about 200,000 mitochondria that generate adenosine triphosphate and
metabolites essential for oocyte development. Mitochondria also integrate metabolism and …

Thymidylate (dTMP) biosynthesis plays an essential and exclusive function in DNA
synthesis and proper cell division, and therefore has been an attractive therapeutic target …

Periconceptional folic acid (FA) supplementation significantly reduces the prevalence of
neural tube defects (NTDs). Unfortunately, some NTDs are FA resistant, and as such, NTDs …

Despite unequivocal evidence that folate deficiency increases risk for human pathologies,
and that folic acid intake among women of childbearing age markedly decreases risk for …

Existing evidence supported that congenital heart defect (CHD) was associated with a
combination of environmental and genetic factors. Based on this, this study aimed at …