Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic
KRAS has been extremely challenging to target therapeutically. To identify potential …

Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …

One of the basic trace elements for the structure and metabolism of human tissue is copper.
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …

Two-photon microscopy (TPM) offers improved deep visualization of the target specimen
with reduced phototoxicity, autofluorescence, and minimal light scattering. In combination …