Potential polymorphic CYP1A2 and CYP2D6-mediated pharmacokinetic interactions between risperidone or olanzapine and selected drugs intended to treat COVID …

A Rojas-Macetas, G Medalla-Garro… - Drug Metabolism …, 2023 - ingentaconnect.com
Risperidone/olanzapine are antipsychotics used in Peru to control symptoms of psychosis.
The objective was to review the available evidence on potential pharmacokinetic …

CYP2D6 and CYP2C19 Genes Associated with Tricontinental and Latin American Ancestry of Peruvians

AT Alvarado, M Saravia, R Losno… - Drug Metabolism …, 2023 - benthamdirect.com
Precision medicine seeks to individualize the dose from the beginning of pharmacological
therapy based on the characteristics of each patient, genes involved in the metabolic …

[PDF][PDF] Serum monitoring of carbamazepine in patients with epilepsy and clinical implications. Pharmacia 69 (2): 401–406

AT Alvarado, G Paredes, G García, A Morales… - 2022 - academia.edu
Carbamazepine is a drug with a narrow therapeutic range that requires clinical monitoring,
since its toxic effects are not easily predictable, and the therapeutic level can vary. Our study …

Associations between Selected ADRB1 and CYP2D6 Gene Polymorphisms in Children with Ventricular and Supraventricular Arrhythmias

E Moric-Janiszewska, S Smolik, L Szydłowski… - Medicina, 2023 - mdpi.com
Background and Objectives: Tachycardia is a common cardiovascular disease. Drugs
blocking β1-adrenergic receptors (ADRB1) are used in the therapy of arrhythmogenic heart …

Serum concentrations of valproic acid in people with epilepsy: Clinical implication

AT Alvarado, J Cotuá, M Delgado… - Journal of Pharmacy …, 2022 - cris.usil.edu.pe
Context: Therapeutic drug monitoring (TDM) allows personalizing the dose of valproic acid
in patients with epilepsy to optimize drug therapy, minimize adverse effects and detect …

[PDF][PDF] Phenytoin concentration in people with epilepsy: A comparative study in serum and saliva. Pharmacia 69 (3): 809–814

A Alvarado, G García, A Morales, G Paredes, M Mora… - 2022 - academia.edu
In clinical practice, therapeutic drug monitoring (TDM) makes it possible to measure the
concentration of drugs in serum or saliva, the purpose of which is to reduce adverse effects …

[PDF][PDF] Pharmacogenetic variants of CYP2C9 and CYP2C19 associated with adverse reactions induced by antiepileptic drugs used in Peru

AT Alvarado, AM Muñoz, N Varela… - …, 2023 - pharmacia.pensoft.net
Epilepsy is the most common neurological disorder with a worldwide incidence of 20% and
a treatment failure rate of 25–30%. The fluctuation in serum levels, efficacy and safety of …

[PDF][PDF] SLCO1B1 and CYP3A4 allelic variants associated with pharmacokinetic interactions and adverse reactions induced by simvastatin and atorvastatin used in …

AT Alvarado, AM Muñoz, RO Ybañez-Julca… - Journal of Pharmacy & …, 2023 - academia.edu
Context: Statins reduce the risk of stroke and prevent cardiac events in people with
atherosclerosis and diabetes mellitus; and could affect the proliferation, migration, and …

[PDF][PDF]  Phenytoin concentration in people with epilepsy: a comparative study in serum and saliva

A Alvarado, G García, A Morales, G Paredes… - …, 2022 - pharmacia.pensoft.net
In clinical practice, therapeutic drug monitoring (TDM) makes it possible to measure the
concentration of drugs in serum or saliva, the purpose of which is to reduce adverse effects …

Application of Bioequivalence Testing of Medicines in Peru

AT Alvarado, V Gray, AM Muñoz, M Saravia… - 2022 - repositorio.uwiener.edu.pe
“This is a review of the current status of drug bioequivalence studies in Peru. A bibliographic
search was conducted in PubMed (Medline database) for bioequivalence studies in Peru …