Pathogenic mutations of human phosphorylation sites affect protein–protein interactions
Despite their lack of a defined 3D structure, intrinsically disordered regions (IDRs) of
proteins play important biological roles. Many IDRs contain short linear motifs (SLiMs) that …
proteins play important biological roles. Many IDRs contain short linear motifs (SLiMs) that …
Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy
M Guo, M He, Y Zhang, W Liu, M Qi, Z Liu… - Cancer Biology & …, 2023 - Taylor & Francis
ABSTRACT Translocation of 14-3-3 protein epsilon (14-3-3ε) was found to be involved in
Triptolide (Tp)-induced inhibition of colorectal cancer (CRC) cell proliferation. However, the …
Triptolide (Tp)-induced inhibition of colorectal cancer (CRC) cell proliferation. However, the …
Transmembrane and coiled-coil domain family 3 gene is a novel target of hepatic peroxisome proliferator-activated receptor γ in fatty liver disease
D Aibara, A Sakaguchi, K Matsusue - Molecular and Cellular …, 2024 - Elsevier
The peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor
abundantly expressed in the nonalcoholic fatty liver disease (NAFLD). In this study, we …
abundantly expressed in the nonalcoholic fatty liver disease (NAFLD). In this study, we …
Exploring Pathogenic Mutations at Phosphorylation Sites through a Peptide-Based Proteomics Screen
T Rrustemi - 2024 - edoc.hu-berlin.de
Approximately 20% of disease-linked point mutations are situated within protein regions
devoid of 3D structure, known as intrinsically disordered regions (IDRs). IDRs harbour short …
devoid of 3D structure, known as intrinsically disordered regions (IDRs). IDRs harbour short …
Drivers of immune resistance in MITFlow melanomas
JM Sax - 2023 - epub.uni-regensburg.de
Immunotherapy with immune checkpoint inhibitors has largely improved survival of
melanoma patients. However, many patients still do not benefit from so far developed …
melanoma patients. However, many patients still do not benefit from so far developed …