Importance Recent clinical and imaging studies underscore that major adverse cardiac
events (MACE) outcomes are associated not solely with severe coronary obstructions …

Coronary angiography has historically served as the gold standard for diagnosis of coronary
artery disease and guidance of percutaneous coronary intervention (PCI). Adjunctive use of …

Background Near-infrared spectroscopy (NIRS) and intravascular ultrasound are promising
imaging modalities to identify non-obstructive plaques likely to cause coronary-related …

Importance Coronary plaques that are prone to rupture and cause adverse cardiac events
are characterized by large plaque burden, large lipid content, and thin fibrous caps. Statins …

Background Acute coronary syndromes most commonly arise from thrombosis of lipid-rich
coronary atheromas that have large plaque burden despite angiographically appearing …

Background: Revascularization is often performed in patients with stable ischemic heart
disease. However, whether revascularization reduces death and other cardiovascular …

Understanding the natural history of coronary artery atherosclerosis is necessary to
determine prognosis and prescribe effective therapies. Traditional management of coronary …

Ultrasound (US) is a biofavorable mechanical wave that has shown practical significance in
biomedical fields. Due to the cavitation effect, sonoluminescence, sonoporation, pyrolysis …

The detection and characterization of coronary artery stenosis and atherosclerosis using
imaging tools are key for clinical decision-making in patients with known or suspected …

Despite advanced understanding of the biology of atherosclerosis, coronary heart disease
remains the leading cause of death worldwide. Progress has been challenging as half of the …