Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

Background: Melatonin is a natural body product that has shown potent antioxidant property
against various toxic agents. For more than two decades, the abilities of melatonin as a …

Patients with human papillomavirus type 16 (HPV)-associated oropharyngeal squamous cell
carcinomas (OPSCC) display increased sensitivity to radiotherapy and improved survival …

The present study was designed to evaluate the influence of long-term environmental
human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the …

Occupational exposure to heavy metals like lead and cadmium causes a wide range of
biological effects and may elevate the risk of genetic damage. Heavy metal toxicity is now …

Background Base-excision repair (BER) is a central DNA repair mechanism responsible for
the maintenance of genome integrity. Accordingly, BER defects have been implicated in …

Although a plethora of studies have examined tobacco smoke-cancer disease association,
the involvement of cellular genetic toxicity remains unclear. Therefore, the present study …

Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer.
However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations …

8-Oxoguanine DNA glycosylase (OGG1) is the major cellular enzyme required for the
excision of 8-oxoguanine DNA base lesions in DNA through the base excision repair (BER) …

Cervical cancer (CaCx) is the malignancy of uterine cervix which induce by human
papillomavirus (HPV) infections. HPV infection starts with the induction of double-stranded …