Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …

Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency
and allows different cell fates to emerge in the developing embryo. MERVL (murine …

The RNA modification N 6-methyladenosine (m6A) has critical roles in many biological
processes,. However, the function of m6A in the early phase of mammalian development …

Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-
zygotic transition,. However, the identity of transcription factors that underlie mammalian …

The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …

The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …