Roles of transposable elements in the regulation of mammalian transcription
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …
contain sequences capable of recruiting the host transcription machinery, which they use to …
Transposable elements shape the evolution of mammalian development
AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …
a short-lived totipotent state. Understanding the process of totipotency in human cells would …
Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …
replication and can be inherited through mitosis. How this may sustain the epigenome and …
Transcription of MERVL retrotransposons is required for preimplantation embryo development
Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency
and allows different cell fates to emerge in the developing embryo. MERVL (murine …
and allows different cell fates to emerge in the developing embryo. MERVL (murine …
The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity
The RNA modification N 6-methyladenosine (m6A) has critical roles in many biological
processes,. However, the function of m6A in the early phase of mammalian development …
processes,. However, the function of m6A in the early phase of mammalian development …
OBOX regulates mouse zygotic genome activation and early development
Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-
zygotic transition,. However, the identity of transcription factors that underlie mammalian …
zygotic transition,. However, the identity of transcription factors that underlie mammalian …
Mechanisms of early placental development in mouse and humans
The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
[HTML][HTML] Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells
M Yang, H Yu, X Yu, S Liang, Y Hu, Y Luo, Z Izsvák… - Cell Stem Cell, 2022 - cell.com
Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …
[HTML][HTML] 8C-like cells capture the human zygotic genome activation program in vitro
J Taubenschmid-Stowers, M Rostovskaya, F Santos… - Cell stem cell, 2022 - cell.com
The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …