Oncolytic adenoviruses (Ads) constitute a promising new class of anticancer agent. They are
based on the well-studied adenoviral vector system, which lends itself to concept-driven …

Simple Summary Animal models are widely used to study various aspects of human
diseases and disorders. Likewise, they are indispensable for preclinical testing of medicals …

Purpose: Tumor targeting upon intravenous administration and subsequent intratumoral
virus dissemination are key features to improve oncolytic adenovirus therapy. VCN-01 is a …

Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing
goal in the field of clinical gene therapy. To achieve this, platform vectors must combine …

Molecular mimicry is one of the leading mechanisms by which infectious agents can induce
autoimmunity. Whether a similar mechanism triggers an antitumor immune response is …

Oncolytic viruses provide a biologically multi-faceted treatment option for patients who
cannot be cured with currently available treatment options. We constructed an oncolytic …

Human adenoviruses (HAdVs) cause widespread acute and persistent infections. Infections
are usually mild and controlled by humoral and cell‐based immunity. Reactivation of …

The dependence of adenovirus on the host pre-RNA splicing machinery for expression of its
complete genome potentially makes it vulnerable to modulators of RNA splicing, such as …

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-
based vaccines demonstrated that these viral vectors can mediate more potent protection …

Public health screening has revealed spread of HAdV outbreak strains to the general
community. Despite expanded awareness of viral respiratory diseases during the SARS …