[HTML][HTML] Vimentin is at the heart of epithelial mesenchymal transition (EMT) mediated metastasis

S Usman, NH Waseem, TKN Nguyen, S Mohsin… - Cancers, 2021 - mdpi.com
Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment

LTH Phi, IN Sari, YG Yang, SH Lee, N Jun… - Stem cells …, 2018 - Wiley Online Library
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

Therapy resistance mediated by cancer stem cells

TB Steinbichler, J Dudás, S Skvortsov… - Seminars in cancer …, 2018 - Elsevier
Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult
stem cells, especially self-renewal and differentiation. The CSC model assumes that this …

[PDF][PDF] ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

C Ginestier, MH Hur, E Charafe-Jauffret, F Monville… - Cell stem cell, 2007 - cell.com
Application of stem cell biology to breast cancer research has been limited by the lack of
simple methods for identification and isolation of normal and malignant stem cells. Utilizing …

The evolving concept of cancer and metastasis stem cells

I Baccelli, A Trumpp - Journal of Cell Biology, 2012 - rupress.org
The cancer stem cell (CSC) concept, which arose more than a decade ago, proposed that
tumor growth is sustained by a subpopulation of highly malignant cancerous cells. These …

Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival

IA Silva, S Bai, K McLean, K Yang, K Griffith, D Thomas… - Cancer research, 2011 - AACR
Markers that reliably identify cancer stem cells (CSC) in ovarian cancer could assist
prognosis and improve strategies for therapy. CD133 is a reported marker of ovarian CSC …

Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer

F Jiang, Q Qiu, A Khanna, NW Todd, J Deepak… - Molecular cancer …, 2009 - AACR
Tumor contains small population of cancer stem cells (CSC) that are responsible for its
maintenance and relapse. Analysis of these CSCs may lead to effective prognostic and …

[HTML][HTML] Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis

CE Eyler, JN Rich - Journal of clinical oncology: official journal of …, 2008 - ncbi.nlm.nih.gov
In an increasing number of cancers, tumor populations called cancer stem cells (CSCs) or
tumor initiating cells have been defined in functional assays of self-renewal and tumor …

Single‐marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase

MR Clay, M Tabor, JH Owen, TE Carey… - Head & …, 2010 - Wiley Online Library
Background In accord with the cancer stem cell (CSC) theory, only a small subset of cancer
cells are capable of forming tumors. We previously reported that CD44 isolates tumorigenic …

Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling

JP Sullivan, M Spinola, M Dodge, MG Raso, C Behrens… - Cancer research, 2010 - AACR
Aldehyde dehydrogenase (ALDH) is a candidate marker for lung cancer cells with stem cell-
like properties. Immunohistochemical staining of a large panel of primary non–small cell …