Growth and remodelling of living tissues: perspectives, challenges and opportunities

D Ambrosi, M Ben Amar, CJ Cyron… - Journal of the …, 2019 - royalsocietypublishing.org
One of the most remarkable differences between classical engineering materials and living
matter is the ability of the latter to grow and remodel in response to diverse stimuli. The …

Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?

JT Ito, JD Lourenço, RF Righetti, IFLC Tibério… - Cells, 2019 - mdpi.com
Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …

Constrained mixture models of soft tissue growth and remodeling–twenty years after

JD Humphrey - Journal of Elasticity, 2021 - Springer
Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

Computational lung modelling in respiratory medicine

S Neelakantan, Y Xin, DP Gaver… - Journal of The …, 2022 - royalsocietypublishing.org
Computational modelling of the lungs is an active field of study that integrates computational
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …

Digital twins for chronic lung diseases

A Gonsard, M Genet… - European Respiratory …, 2024 - publications.ersnet.org
Digital twins have recently emerged in healthcare. They combine advances in cyber–
physical systems, modelling and computation techniques, and enable a bidirectional flow of …

Pathobiology of airway remodeling in asthma: the emerging role of integrins

C Joseph, AL Tatler - Journal of Asthma and Allergy, 2022 - Taylor & Francis
Airway remodeling is a complex clinical feature of asthma that involves long-term disruption
and modification of airway architecture, which contributes significantly to airway …

[HTML][HTML] Mechanical behavior of the airway wall in respiratory disease

M Maghsoudi-Ganjeh, S Sattari, M Eskandari - Current Opinion in …, 2021 - Elsevier
The biomechanical behavior of the airways can be altered due to pathological remodeling,
causing obstruction and limiting airflow. Airway damaging lung diseases, such as asthma …

[HTML][HTML] Mechanobiology of Type 1 hypersensitivity: Elucidating the impacts of mechanical forces in allergic reactions

H Sutanto - Mechanobiology in Medicine, 2024 - Elsevier
Type 1 hypersensitivity involves an exaggerated immune reaction triggered by allergen
exposure, leading to rapid release of inflammatory mediators. Meanwhile, mechanobiology …

Complementary roles of mechanotransduction and inflammation in vascular homeostasis

M Latorre, B Spronck… - Proceedings of the …, 2021 - royalsocietypublishing.org
Arteries are exposed to relentless pulsatile haemodynamic loads, but via mechanical
homeostasis they tend to maintain near optimal structure, properties and function over long …

Airway remodelling with spatial correlations: Implications for asthma pathogenesis

CD Pascoe, FHY Green, JG Elliot, AL James… - Respiratory Physiology …, 2020 - Elsevier
Airway remodelling is a cardinal feature of asthma in which airways undergo structural
changes-in particular, increased airway smooth muscle mass and total airway wall area …