Resistance to the insulin and elevated level of androgen: A major cause of polycystic ovary syndrome

H Ding, J Zhang, F Zhang, S Zhang, X Chen… - Frontiers in …, 2021 - frontiersin.org
PCOS has a wide range of negative impacts on women's health and is one of the most
frequent reproductive systemic endocrine disorders. PCOS has complex characteristics and …

Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper

S Palomba - Human Reproduction, 2021 - academic.oup.com
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility;
however, whether women with PCOS and spontaneous or drug-induced ovulatory cycles …

The epidermal growth factor network: role in oocyte growth, maturation and developmental competence

D Richani, RB Gilchrist - Human reproduction update, 2018 - academic.oup.com
BACKGROUND The LH surge induces great physiological changes within the preovulatory
follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting …

Oocyte competence in women with polycystic ovary syndrome

S Palomba, J Daolio, GB La Sala - Trends in Endocrinology & Metabolism, 2017 - cell.com
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age and affects fertility and pregnancy in cases of oligoanovulation. Ovulation …

The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo

J Castillo, M Jodar, R Oliva - Human reproduction update, 2018 - academic.oup.com
BACKGROUND Knowledge of the proteomic composition of the gametes is essential to
understand reproductive functions. Most of the sperm proteins are related to …

Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India

MA Ganie, V Vasudevan, IA Wani… - Indian Journal of …, 2019 - journals.lww.com
Polycystic ovary syndrome (PCOS) is a common endocrine disorder predominantly affecting
women of reproductive age. Clinical manifestations are diverse including …

Estradiol signaling at the heart of folliculogenesis: its potential deregulation in human ovarian pathologies

S Chauvin, J Cohen-Tannoudji, CJ Guigon - International journal of …, 2022 - mdpi.com
Estradiol (E2) is a major hormone controlling women fertility, in particular folliculogenesis.
This steroid, which is locally produced by granulosa cells (GC) within ovarian follicles …

S100‐A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF‐κB pathway in polycystic ovary syndrome

H Li, X Huang, X Chang, J Yao, Q He… - Journal of cellular …, 2020 - Wiley Online Library
Exosomes have recently emerged as key mediators of different physiological and
pathological processes. However, there has been few report about proteomic analysis of …

Follicular fluid composition and reproductive outcomes of women with polycystic ovary syndrome undergoing in vitro fertilization: A systematic review

MV Moreira, E Vale-Fernandes, IC Albergaria… - Reviews in Endocrine …, 2023 - Springer
Polycystic ovary syndrome (PCOS) is recognized as one of the most prevalent
endocrinopathy in women at reproductive age. As affected women tend to have poorer …

DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

P Sagvekar, P Kumar, V Mangoli, S Desai… - Clinical …, 2019 - Springer
Background Women with polycystic ovary syndrome (PCOS) manifest a host of ovarian
defects like impaired folliculogenesis, anovulation, and poor oocyte quality, which grossly …