[HTML][HTML] Age-Related Macular Degeneration (AMD): Pathophysiology, Drug Targeting Approaches, and Recent Developments in Nanotherapeutics

M Singh, R Negi, Alka, R Vinayagam, SG Kang… - Medicina, 2024 - mdpi.com
The most prevalent reason for vision impairment in aging inhabitants is age-related macular
degeneration (AMD), a posterior ocular disease with a poor understanding of the anatomic …

Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases

J Wißfeld, T Abou Assale, G Cuevas-Rios… - Frontiers in …, 2024 - frontiersin.org
Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian
cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the …

Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells

LH Geraldo, Y Xu, G Mouthon, J Furtado… - Science Translational …, 2024 - science.org
Roundabout (ROBO) 1 and 2 are transmembrane receptors that bind secreted SLIT ligands
through their extracellular domains (ECDs) and signal through their cytoplasmic domains to …

Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age …

MJ Tolentino, AJ Tolentino, EM Tolentino, A Krishnan… - Pharmaceuticals, 2023 - mdpi.com
Age-related macular degeneration (AMD), a leading cause of visual loss and dysfunction
worldwide, is a disease initiated by genetic polymorphisms that impair the negative …

[HTML][HTML] Advances in understanding and exploiting Siglec–glycan interactions

Z Jame-Chenarboo, TE Gray, MS Macauley - Current Opinion in Chemical …, 2024 - Elsevier
Sialic-acid-binding immunoglobulin-type lectins (Siglecs) are a family of cell-surface
immunomodulatory receptors that recognize sialic-acid-containing glycans. The majority of …

Decreased sialylation elicits complement‐related microglia response and bipolar cell loss in the mouse retina

G Cuevas‐Rios, TA Assale, J Wissfeld, A Bungartz… - Glia, 2024 - Wiley Online Library
Sialylation plays an important role in self‐recognition, as well as keeping the complement
and innate immune systems in check. It is unclear whether the reduced sialylation seen …

Comprehensive Ocular and Systemic Safety Evaluation of Polysialic Acid-Decorated Immune Modulating Therapeutic Nanoparticles (PolySia-NPs) to Support Entry …

A Krishnan, DG Callanan, VG Sendra, A Lad… - Pharmaceuticals, 2024 - mdpi.com
An inflammation-resolving polysialic acid-decorated PLGA nanoparticle (PolySia-NP) has
been developed to treat geographic atrophy/age-related macular degeneration and other …

PolySialic Acid Nanoparticles Actuate Complement-Factor-H-Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related …

SL Peterson, A Krishnan, D Patel, A Khanehzar, A Lad… - Pharmaceuticals, 2024 - mdpi.com
The alternative pathway of the complement system is implicated in the etiology of age-
related macular degeneration (AMD). Complement depletion with pegcetacoplan and …