Nicotinic receptors: From protein allostery to computational neuropharmacology
M Cecchini, JP Changeux - Molecular Aspects of Medicine, 2022 - Elsevier
We propose an extension and further development of the Monod-Wyman-Changeux model
for allosteric transitions of regulatory proteins to brain communications and specifically to …
for allosteric transitions of regulatory proteins to brain communications and specifically to …
Agonist efficiency links binding and gating in a nicotinic receptor
DC Indurthi, A Auerbach - Elife, 2023 - elifesciences.org
Receptors signal by switching between resting (C) and active (O) shapes ('gating') under the
influence of agonists. The receptor's maximum response depends on the difference in …
influence of agonists. The receptor's maximum response depends on the difference in …
Dynamics of receptor activation by agonists
A Auerbach - Biophysical Journal, 2024 - cell.com
How do agonists turn on receptors? The model system we have used to address this
question is the adult-type skeletal muscle nicotinic acetylcholine receptor. This ligand-gated …
question is the adult-type skeletal muscle nicotinic acetylcholine receptor. This ligand-gated …
Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer
The lipid dependence of the nicotinic acetylcholine receptor from the Torpedo electric organ
has long been recognized, and one of the most consistent experimental observations is that …
has long been recognized, and one of the most consistent experimental observations is that …
A critical residue in the α1M2–M3 linker regulating mammalian GABAA receptor pore gating by diazepam
JW Nors, S Gupta, MP Goldschen-Ohm - Elife, 2021 - elifesciences.org
Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that modulate
activity of GABAA receptors (GABAARs), neurotransmitter-gated ion channels critical for …
activity of GABAA receptors (GABAARs), neurotransmitter-gated ion channels critical for …
Structural determinants and regulation of spontaneous activity in GABAA receptors
CA Sexton, R Penzinger, M Mortensen… - Nature …, 2021 - nature.com
GABAA receptors are vital for controlling neuronal excitability and can display significant
levels of constitutive activity that contributes to tonic inhibition. However, the mechanisms …
levels of constitutive activity that contributes to tonic inhibition. However, the mechanisms …
The glycine receptor allosteric ligands library (GRALL)
AH Cerdan, M Sisquellas, G Pereira… - …, 2020 - academic.oup.com
Abstract Motivation Glycine receptors (GlyRs) mediate fast inhibitory neurotransmission in
the brain and have been recognized as key pharmacological targets for pain. A large …
the brain and have been recognized as key pharmacological targets for pain. A large …
[HTML][HTML] A single molecular distance predicts agonist binding energy in nicotinic receptors
S Tripathy, W Zheng, A Auerbach - The Journal of General …, 2019 - ncbi.nlm.nih.gov
Agonists turn on receptors because they bind more strongly to active (R*) versus resting (R)
conformations of their target sites. Here, to explore how agonists activate neuromuscular …
conformations of their target sites. Here, to explore how agonists activate neuromuscular …
The effect of unliganded gating on agonist response in nicotinic receptors
DC Indurthi - European Journal of Pharmacology, 2024 - Elsevier
Understanding the agonist concentration-response curve (CRC) is the cornerstone in
pharmacology. While CRC parameters, agonist potency (EC 50) and efficacy (maximum …
pharmacology. While CRC parameters, agonist potency (EC 50) and efficacy (maximum …
Conformational dynamics of a nicotinic receptor neurotransmitter binding site
Agonists turn on receptors because they provide net favorable binding energy to active
versus resting conformations of their target sites. We used simulations to explore …
versus resting conformations of their target sites. We used simulations to explore …