ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …

Highlights•The antibiotic resistance crisis is jeopardizing feasibility of medical practices.•The
antibiotic resistance crisis is more serious with Gram-negative pathogens.•XDR phenotypes …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

We evaluated the number of deaths attributable to carbapenem-resistant
Enterobacteriaceae by using studies from around the world published before April 9, 2012 …

Klebsiella pneumoniae strains producing KPC-type carbapenemases (KPC-KP) are
challenging multidrug-resistant pathogens due to their extensively drug-resistant …

Hospital-acquired pneumonia and ventilator-associated pneumo... : Current Opinion in
Pulmonary Medicine Hospital-acquired pneumonia and ventilator-associated pneumonia …