Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …

Having been debated for many years, the presence and role of spermatozoal RNAs is
resolving, and their contribution to development is now appreciated. Data from different …

The study of the boar sperm transcriptome by RNA-seq can provide relevant information on
sperm quality and fertility and might contribute to animal breeding strategies. However, the …

Major difficulties exist in the accurate and meaningful diagnosis of male reproductive
dysfunction, and our understanding of the epidemiology and etiology of male infertility has …

Potentiation is the transition from higher-order, transcriptionally silent chromatin to a less
condensed state requisite to accommodating the molecular elements required for …

The former perception of the spermatozoon as a delivery device of the male genome has
been expanded to include a new understanding of the cell's complex role in fertilization …

Background Understanding the regulatory processes that coordinate the cascade of gene
expression leading to male gamete development has proven challenging. Research has …

Systems biology presents a new paradigm for elucidating the processes required to
organize and sustain life. We now have access to whole genome sequences, gene …

At fertilization, the male germ cell conveys a richly layered genetic landscape consisting of
both DNA and its associated epigenetic information. A systems level understanding of these …

In biology, the nuclear matrix is the nuclear cytoskeleton. Matrix Attachment Regions (MAR)
are regions of the DNA attached to this nuclear matrix. These Matrix Attachment Regions is …