Autophagy, an intracellular conserved degradative process, plays a central role in the
renewal/recycling of a cell to maintain the homeostasis of nutrients and energy within the …

Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-
resistance by tumor cells represents a primary obstacle for successful chemotherapy …

Macroautophagy is a process in which cytoplasmic components, including whole
organelles, are degraded within lysosomes. Basally, this process is essential for …

Background Mutations in CTNS—a gene encoding the cystine transporter cystinosin—cause
the rare, autosomal, recessive, lysosomal-storage disease cystinosis. Research has also …

Human neutrophil elastase (HNE) is an important N-glycosylated serine protease in the
innate immune system, but the structure and immune-modulating functions of HNE N …

This review is the eighth update of the original article published in 1999 on the application of
Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry …

The discovery of the causative gene for Huntington's disease (HD) has promoted numerous
efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and …

Asparagine (N)-linked protein glycosylation, which takes place in the eukaryotic
endoplasmic reticulum (ER), is important for protein folding, quality control and the …

Unlike complex glycosylations, O-GlcNAcylation consists of the addition of a single N-
acetylglucosamine unit to serine and threonine residues of target proteins, and is confined …

N-glycans on glycoproteins serve as one of the most important co-and post-translational
modifications of proteins, and it has been well established that they play pivotal roles in …