ATG5: A central autophagy regulator implicated in various human diseases
Autophagy, an intracellular conserved degradative process, plays a central role in the
renewal/recycling of a cell to maintain the homeostasis of nutrients and energy within the …
renewal/recycling of a cell to maintain the homeostasis of nutrients and energy within the …
Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy
Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-
resistance by tumor cells represents a primary obstacle for successful chemotherapy …
resistance by tumor cells represents a primary obstacle for successful chemotherapy …
Retrograde signaling from autophagy modulates stress responses
Macroautophagy is a process in which cytoplasmic components, including whole
organelles, are degraded within lysosomes. Basally, this process is essential for …
organelles, are degraded within lysosomes. Basally, this process is essential for …
Use of human induced pluripotent stem cells and kidney organoids to develop a cysteamine/mTOR inhibition combination therapy for cystinosis
Background Mutations in CTNS—a gene encoding the cystine transporter cystinosin—cause
the rare, autosomal, recessive, lysosomal-storage disease cystinosis. Research has also …
the rare, autosomal, recessive, lysosomal-storage disease cystinosis. Research has also …
Paucimannose-Rich N-glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions*.
I Loke, O Østergaard, NHH Heegaard… - Molecular & Cellular …, 2017 - ASBMB
Human neutrophil elastase (HNE) is an important N-glycosylated serine protease in the
innate immune system, but the structure and immune-modulating functions of HNE N …
innate immune system, but the structure and immune-modulating functions of HNE N …
Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2013–2014
DJ Harvey - Mass Spectrometry Reviews, 2018 - Wiley Online Library
This review is the eighth update of the original article published in 1999 on the application of
Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry …
Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry …
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
I Al-Ramahi, SSP Giridharan, YC Chen, S Patnaik… - elife, 2017 - elifesciences.org
The discovery of the causative gene for Huntington's disease (HD) has promoted numerous
efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and …
efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and …
Generation and degradation of free asparagine-linked glycans
Y Harada, H Hirayama, T Suzuki - Cellular and molecular life sciences, 2015 - Springer
Asparagine (N)-linked protein glycosylation, which takes place in the eukaryotic
endoplasmic reticulum (ER), is important for protein folding, quality control and the …
endoplasmic reticulum (ER), is important for protein folding, quality control and the …
The Many Ways by Which O-GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations
J Biwi, C Biot, Y Guerardel, AS Vercoutter-Edouart… - Molecules, 2018 - mdpi.com
Unlike complex glycosylations, O-GlcNAcylation consists of the addition of a single N-
acetylglucosamine unit to serine and threonine residues of target proteins, and is confined …
acetylglucosamine unit to serine and threonine residues of target proteins, and is confined …
Catabolism of N-glycoproteins in mammalian cells: Molecular mechanisms and genetic disorders related to the processes
T Suzuki - Molecular aspects of medicine, 2016 - Elsevier
N-glycans on glycoproteins serve as one of the most important co-and post-translational
modifications of proteins, and it has been well established that they play pivotal roles in …
modifications of proteins, and it has been well established that they play pivotal roles in …