Tissue homeostasis requires a carefully-orchestrated balance between cell proliferation,
cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly …

Radiotherapy plays an important role in the management of breast cancer. Whilst its role in
achieving local control following surgery in patients with early stage cancer is well …

The aim of this study was to investigate the occurrence of (pre) neoplastic lesions in overtly
normal Fallopian tubes from women predisposed to developing ovarian carcinoma. The …

Aberrant inhibition of programmed cell death (apoptosis) prevents normal homeostasis and
promotes tissue tumorigenesis, but whether it also influences the outcome of common …

Purpose: Prognostication of breast cancer using clinicopathologic variables, although
useful, remains imperfect. Many reports suggest that gene expression profiling can refine the …

Pluronic block copolymer P85 (P85) sensitizes multidrug resistant (MDR) cancer cells
resulting in the increase of cytotoxic activity of antineoplastic agents. This effect is attributed …

Sodium butyrate (NaBu) can enhance the expression of genes from some of the mammalian
promoters including cytomegalovirus (CMV) and simian virus 40 (SV40), but it can also …

Independent of its antiapoptotic function, Bcl-2 can, through an undetermined mechanism,
retard entry into the cell cycle. Cell cycle progression requires the phosphorylation by cyclin …

BACKGROUND: The use of adjuvant chemotherapy in early breast carcinoma is
controversial, with most advocating its use in high-risk patients as defined by specific …

Homeostasis in normal tissue is regulated by a balance between proliferative activity and
cell loss by apoptosis. Apoptosis is a physiological mechanism of cell loss that depends on …