Developments towards synthesis of N-heterocycles from amidines via C–N/C–C bond formation

W Guo, M Zhao, W Tan, L Zheng, K Tao… - Organic Chemistry …, 2019 - pubs.rsc.org
The synthesis of N-heterocycles is one of the most active areas due to their structures with
extensive applications in the fields of organic, pharmaceutical and materials chemistry. It is …

2-Aminopyridine–an unsung hero in drug discovery

RN Rao, K Chanda - Chemical Communications, 2022 - pubs.rsc.org
2-Aminopyridine is a simple, low molecular weight and perfectly functionalised moiety
known for the synthesis of diverse biological molecules. Many pharmaceutical companies …

Metal-free oxidative cyclization of 2-aminobenzothiazoles and cyclic ketones enabled by the combination of elemental sulfur and oxygen

Y Xie, X Chen, Z Wang, H Huang, B Yi, GJ Deng - Green Chemistry, 2017 - pubs.rsc.org
Metal-free oxidative cyclization for the one-pot synthesis of benzo [d] imidazo [2, 1-b]
thiazoles from 2-aminobenzothiazoles and cyclic ketones is described. Elemental sulfur …

Access to Imidazo[1,2-a]pyridines via Annulation of α-Keto Vinyl Azides and 2-Aminopyridines

PR Adiyala, GS Mani, JB Nanubolu, KC Shekar… - Organic …, 2015 - ACS Publications
A novel strategy for the synthesis of imidazo [1, 2-a] pyridines via efficient catalyst/metal-free
annulations of α-keto vinyl azides and 2-aminopyridines is described. Several imidazo [1, 2 …

α-Aminoazoles/azines: key reaction partners for multicomponent reactions

S Imtiaz, S Banoo - RSC advances, 2021 - pubs.rsc.org
Aromatic α-aminoazaheterocycles are the focus of significant investigations and exploration
by researchers owing to their key role in diverse biological and physiological processes. The …

Diverse synthesis of pyrimido [1, 2-a] benzimidazoles and imidazo [2, 1-b] benzothiazoles via CuI-catalyzed decarboxylic multicomponent reactions of heterocyclic …

J Wu, H Luo, T Wang, H Sun, Q Zhang, Y Chai - Tetrahedron, 2019 - Elsevier
We have developed a straightforward approach to diverse synthesis of 2, 3-, 2, 4-
disubstituted pyrimido [1, 2-a] benzimidazoles, 2, 4, 10-trisubstituted 2, 10-dihydropyrimido …

Diversity-oriented synthesis of imidazo-dipyridines with anticancer activity via the Groebke–Blackburn–Bienaymé and TBAB-mediated cascade reaction in one pot

Y Li, JH Huang, JL Wang, GT Song… - The Journal of …, 2019 - ACS Publications
A facile and metal-free one-pot protocol for the synthesis of fused imidazopyridine scaffolds
has been developed. This novel protocol combines the Groebke–Blackburn–Bienaymé …

Copper-Promoted Cycloaddition of α-Methylenyl Isocyanides with Benzothiazoles: Tunable Access to Benzo[d]imidazothiazoles

J Wang, J Li, Q Zhu - Organic letters, 2015 - ACS Publications
A tunable route to both isomers of benzo [d] imidazothiazole has been developed through
copper-promoted cycloaddition of α-methylenyl isocyanides with benzothiazoles. When the …

Recent developments towards the synthesis of pyrimidopyrimidine and purine derivatives

P Debnath - ChemistrySelect, 2023 - Wiley Online Library
Fused pyrimidines scaffolds such as pyrimidopyrimidines, purines and xanthines are
important structural motifs found in various natural products and drug molecules. They are …

General Entry into o‐,o′‐Heteroatom‐Linked N‐(Hetero)aryl‐Imidazole Motifs by Gold‐Catalysed Formal [3+2]‐Dipolar Cycloaddition

M Garzón, EM Arce, RJ Reddy… - Advanced Synthesis & …, 2017 - Wiley Online Library
A general redox‐neutral approach into the o‐, o′‐heteroatom‐linked N‐(hetero) aryl‐
imidazole family of heteroaromatics has been developed. New types of heteroatom …