PURPOSE Prospective data on the efficacy of a watch-and-wait strategy to achieve organ
preservation in patients with locally advanced rectal cancer treated with total neoadjuvant …

Background Low rectal cancers could be treated using restorative (anterior resection, AR) or
non-restorative procedures with an end/permanent stoma (Hartmann's, HE; or …

Rectal resection surgery after neoadjuvant treatment has been the mainstay treatment of
locally advanced rectal cancer. However, functional outcomes and quality of life after radical …

Background Results from the phase 3 PRODIGE 23 study showed that neoadjuvant
chemotherapy (NAC) with mFOLFIRINOX and preoperative chemoradiotherapy improved …

Background The impact of bowel dysfunction versus colostomy on quality of life after rectal
cancer surgery is poorly understood. Background To evaluate the quality of life after rectal …

Aim This study examines the burden of colorectal cancer (CRC) in European Union (EU)
countries in the last 3 decades. Methods The data pertaining to CRC burden were procured …

Importance The risk of recurrence in patients with locally advanced rectal cancer has
historically been determined after surgery, relying on pathologic variables. A growing …

Simple Summary At the last 2022 annual ASCO meeting, impressive results of anti-PD1
activity in clinical stage 2 and 3 microsatellite instable rectal cancer patients have been …

Background: The watch-and-wait (W&W) strategy is a novel treatment option for patients with
rectal cancer who have a strong desire for organ preservation. The study aimed to explore …

Background: This prospective randomized controlled study was designed to evaluate the
effect of biofeedback therapy (BFT) during temporary stoma period to prevent defecation …